منابع مشابه
Novel Mediator of Sodium Chloride–Dependent Hypertension
Background—Digitalis-like sodium pump ligands (SPLs) effect natriuresis via inhibition of renal tubular Na ,K -ATPase but may induce vasoconstriction. The present study investigated the potential roles of 2 putative endogenous SPLs, an ouabain-like compound (OLC) and an 1 Na ,K -ATPase inhibitor, marinobufagenin (MBG), in regulating natriuresis and blood pressure (BP) responses to sustained and...
متن کاملEndogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension.
BACKGROUND Digitalis-like sodium pump ligands (SPLs) effect natriuresis via inhibition of renal tubular Na(+),K(+)-ATPase but may induce vasoconstriction. The present study investigated the potential roles of 2 putative endogenous SPLs, an ouabain-like compound (OLC) and an alpha(1) Na(+),K(+)-ATPase inhibitor, marinobufagenin (MBG), in regulating natriuresis and blood pressure (BP) responses t...
متن کاملSodium chloride and aldosterone: harbingers of hypertension-related cardiovascular disease.
Both dietary NaCl consumption and aldosterone have been implicated in the pathogenesis of hypertensionrelated cardiovascular disease. Animal, epidemiological, and clinical studies suggest that a high NaCl intake is associated with myocardial hypertrophy, independent of blood pressure. In vitro, NaCl directly induces hypertrophy in myocardial and vascular smooth muscle cells. Independent of the ...
متن کاملContributions of sodium and chloride to NaCl-induced hypertension.
The recommendation to avoid high dietary “salt” intake for the prevention and treatment of hypertension is often expressed in terms of dietary sodium. However, a consistent body of evidence suggests that the chloride component of salt is an important contributor to NaClinduced elevations of blood pressure.1 In several rat models of salt-sensitive hypertension (Dahl salt-sensitive [S] rat, DOCA-...
متن کاملSodium chloride
Human toxicity High NaCl intake without corresponding intake of water can lead to hypernatremia: the ratio of sodium to water exceeds normal, and both the plasma sodium concentration and the total body sodium increase. Consequently, the balance of extracellular and intracellular osmolality is disturbed, which can result in several clinical symptoms, like excessive thirst, weakness, headache, ir...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1986
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.8.4.359